Science behind nugevia

The Resveratrol
Revolution

Resveratrol is a powerful polyphenol found in red wine, grapes, and berries—long celebrated for its antioxidant, anti-inflammatory, and longevity-promoting properties. Decades of research have linked resveratrol to improved brain health, cellular resilience, and neuroprotection, yet most supplements deliver less than 1% bioavailability.

For decades, researchers have documented resveratrol's power to activate SIRT1 longevity genes, enhance mitochondrial function, and provide neuroprotection. Now, JOTROL™ micellar technology finally solves resveratrol's absorption and bioavailability problem, delivering 9 fold higher bioavailability at maximum blood concentration and faster absorption so your body actually experiences the cellular anti-aging benefits that research promises.

The Bioavailability Challenge

Why traditional resveratrol falls short despite compelling lab results, standard resveratrol supplements have struggled to deliver on their promise in human trials due to:

<1% bioavailability

Rapid metabolism and clearance

GI side effects at high doses

Inconsistent CNS penetration

The JOTROL™ Difference

Solving bioavailability with smart delivery, JOTROL™ is a patented micellar formulation of resveratrol designed for optimal absorption, maximizing blood concentrations and CNS delivery.

Challenges

Bioavailability

Brain Penetration

Dosing

Side Effects

Standard Resveratrol

<1%

Inconsistent

Gram-Level

GI Issues

JOTROL™

Up To 9x Higher

Proven CNS Delivery

Milligram Level

Well-Tolerated

How JOTROL™ Works

Micellar technology with a purpose, JOTROL™ uses advanced micellar delivery to:

Encapsulate resveratrol in micelles for better gut absorption and improve peak blood levels

Protect it from rapid metabolism

Improve blood-brain barrier crossing

Enable therapeutic CNS and cellular levels at lower doses

A landmark study by Turner et al. (2015) demonstrated that resveratrol can cross the blood-brain barrier and influence key biomarkers like MMP-9, Aβ40, and tau in Alzheimer’s patients but only at high, hard-to-tolerate doses.

Turner RS, Thomas RG, Craft S, et al. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015;85(16):1383-1391. doi:10.1212/WNL.0000000000002035

The University of New Mexico

Mitochondrial Power

The Engine of Healthy Aging

Mitochondria power every aspect of healthy aging from mental clarity to physical endurance. JOTROL™ enhanced resveratrol activates key longevity pathways with faster absorption, ensuring your cells actually receive the mitochondrial support that research promises.

SIRT1 + PGC-1α

Boost mitochondrial biogenesis

Reduce ROS

Lower oxidative stress in aging neurons

Increase ATP

Support cognitive and physical performance

AMPK

Enhance energy efficiency and metabolic resilience

Traditional Resveratrol Limitations

Traditional resveratrol supplements face significant challenges that have limited their therapeutic potential.

Absorption Challenge

Poor oral bioavailability requiring extremely high doses (3–5 grams) to achieve therapeutic blood levels.
Rapid metabolism and elimination from the body.
Poor bioavailability due to first-pass liver metabolism

Gastrointestinal Issues

Doses above 1 gram commonly cause digestive discomfort.
At therapeutic doses (2+ grams), severe GI issues are nearly inevitable.
These side effects often force discontinuation of treatment.

The JOTROL™ Advantage

9x higher bioavailability means lower doses needed.
Proprietary formulation eliminates dose-limiting GI side effects.
Maintains therapeutic effectiveness without digestive discomfort.
Clinical studies show no GI toxicity at effective doses.

Safety Considerations

Always consult healthcare providers before starting any resveratrol supplement.
Higher doses of traditional resveratrol may interact with certain medications.
Individual tolerance levels vary significantly.

Why It Matters

Resveratrol may slow cognitive decline and protect neurons, but we've lacked a good delivery method.

With JOTROL™, we can finally bridge the gap between hope and impact—advancing neuroprotection, longevity, and healthy brain aging through proven science and superior bioavailability.

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Developed with Clinical Grade Research

Absorption

One Core. Three Missions.

Each Nugevia formula pairs high-bioavailability resveratrol (JOTROL™) with a targeted second active, designed for synergistic activation of longevity, performance, and protection.

GLO

Daily Skin Resilience

Visible Radiance

Cellular Protection

JOTROL™ enhanced resveratrol

Astaxanthin for membrane defense

PWR

Mitochondria & Muscle Strength

Enhanced endurance

Cardiovascular support

JOTROL™ enhanced resveratrol

CoQ10 for cellular power

MND

Cognitive Clarity & Brain Aging Support

Sharp mental performance

Neuronal defense

JOTROL™ enhanced resveratrol

Curcumin for cognitive support

chosen by experts

See why experts trust Nugevia

“This is a supplement I use myself everyday to be as healthy as I can, for as long as I can.”

Annika Sörenstam

Professional Golfer

Trusted by global professionals

Clinical Studies

JOTROL, a novel formulation of Resveratrol, shows beneficial effects in the 3xTg-AD mouse model

Safety and pharmacokinetics of a highly bioavailable resveratrol preparation (JOTROL TM)

An open-label trial in Friedreich ataxia suggests clinical benefit with high-dose resveratrol, without effect on frataxin levels

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

Resveratrol Attenuates CSF Markers of Neurodegeneration and Neuroinflammation in Individuals with Alzheimer’s Disease

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

View More Studies

Your Questions, Answered

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.